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KMID : 0828520130170020079
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Journal of the Korean Geriatrics Society
2013 Volume.17 No. 2 p.79 ~ p.85
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Helical Tomotherapy in Elderly Prostate Cancer Patients
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Ki Yong-Kan
Nam Ji-Ho
Kim Won-Taek
Park Dahl
Kim Dong-Hyun
Lee Ju-Hye
Jeon Ho-Sang
Kim Dong-Won
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Abstract
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Background: Helical tomotherapy is new form of image-guided intensity modulated radiation therapy that may improve local control and decrease radiation toxicity. The aim of this study was to evaluate if helical tomotherapy with high dose is tolerable in patients aged 75 years or older, and if the side effects are comparable than younger patients. Methods: Between January 2011 and August 2012, the patients with prostate cancer who underwent helical tomotherapy without elective pelvic irradiation as definitive aim were reviewed and were divided into two age groups: ≥ 75 years and < 75 years. The acute genitourinary (GU) and lower gastrointestinal (GI) toxicities between the two groups were compared. Results: Twenty patients aged 75 years or older and 23 patients younger than 75 years were evaluated. Radiotherapy was administered to a total dose of 76-78 Gy in 38-39 fractions or 70 Gy in 28 fractions. There was no grade 3 or 4 acute toxicity and no grade 2 acute lower GI symptom, whereas the patients complained grade 2 acute GU toxicity; 25.0% for the older group and 13.0% for the younger group. There was no significant difference in the rate of acute toxicity between the age groups. Hypofractionation showed the significant association with higher grade 2 acute GU toxicity (p=0.024), but grade 2 acute GU toxicity had no significant correlation with T-stage, Gleason score, PSA level, androgen deprivation therapy and comorbidities.
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KEYWORD
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Helical tomotherapy, Prostate cancer, Elderly
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